Serie A leaders Inter Milan are away at Napoli knowing that defeat will see them lose their position at the top.
Inter are coming off a 2-1 loss to rivals AC Milan but remain top of the standings with 53 points.
Napoli are hot on their heels with 52 points, level with third-place Milan.
Napoli are unbeaten in 14 of their last 15 Serie A home games against Inter, with their only defeat during that time being a 3-1 reverse in January 2020.
Who will be atop the Italian league after this weekend? Play here to make your predictions.
What time does Napoli vs Inter start?
The game kicks off at 17 UTC at the Stadio Diego Armando Maradona.
Napoli vs Inter team news
The hosts are without Kalidou Koulibaly, having only just returned to Italian soil from winning the Africa Cup of Nations with Senegal.
Adam Ounas and Hirving Lozano are still not fully fit and could also miss out on the game.
Top scorer Victor Osimhen is set to start up front, supported by Dries Mertens and Andrea Petagna.
For the visitors, Robin Gosens and Joaquin Correa are still sidelined injuries.
Aside from they they have a full squad to choose from with Lautaro Martinez and Edin Dzeko leading the attacking line.
Napoli vs Inter head to head
The hosts have the edge, winning 14 times out of the 37 games played between these two sides.
Inter have been victorious 13 times and the remaining 10 have resulted in a stalemate.
Napoli vs Inter current form
Both teams have only one loss to their name in the last five matches. Napoli have won the remaining four, whilst Inter have won thrice and drawn another.
Napoli vs Inter prediction
This will be a cracker of an encounter and with the form Napoli are on, they may just edge their opponents on the night.